Chevrolet gave you a chance to get used to the 2020 Silverado HD’s imposing visage, and now it’s showing you how many expressions the heavy-duty truck can make. The five different trim levels for the upcoming pickup have been revealed, and they run the gamut from sober through to glitzy. Story Timeline2019 Chevrolet Silverado adds tech, drops weight, snarks F-150Chevy teases all-new 2020 Silverado HD2019 Chevrolet Silverado 1500 engines detailed with Turbo-4 surprise The line-up will include the Silverware HD Work Truck, Custom, LT, LTZ, and High Country. While that might sound like a lot, it’s actually fairly restrained in comparison to the array of trims Chevy offers on the smaller Silverado 1500. That comes in no fewer than eight different trims. Top of the range will be the 2020 Silverado HD High Country. That will have a two-tone metallic trim, among other exterior details like lashings to chrome. High Country branding will be punched into the distinctive grille bar which spans the front of the truck. Other models will be more focused on work rather than fashion. The Work Truck, for instance, will be the most focused of the range, while the remaining three will slot in-between with different tech and styling. Some grilles will have the Chevrolet stamped bar on the grille, while others will have automaker’s bowtie. Trims will be finished in either black, body color, or chrome. AdChoices广告Exactly how well those combinations will work, we’ll have to wait to find out. So far, Chevy has only shown images of the High Country and the 2020 Silverado HD LT. The former is as shiny and eye-catching as you’d expect from a flagship truck, while the latter is more restrained, though still not short on brightwork. What we do know is the engine options. The 2020 Silverado HD will launch with choice of an all-new direct injection gas engine, with a six speed transmission, or a Durmax Turbo-Diesel V8 with an Allison 10 speed transmission. We only currently have torque numbers for the diesel, but they don’t disappoint with its 910 lb-ft. on tap. Inside there’ll be more legroom in the crew cab models, and a boost in technology, too. We’re expecting features like Android Auto and Apple CarPlay, which Chevrolet already offered in the Silverado 1500, together with easier to use controls and probably a 4G LTE embedded connection with WiFi hotspot support. Full spec details – and images of the other three trims – will come closer to the 2020 Silverado HD’s launch. That’s expected to take place in mid-2019.
Microsoft To-Do has admittedly come a long way since its first release. Back then, it was inconceivable for Wunderlist fans that it would take the place of their beloved app. Those will probably still find MS To-Do pales in comparison but others may finally be able to migrate to the app now that it’s available practically everywhere and with mostly the same features.On macOS, Microsoft To-Do has two forms. Pressing ⌘2 activates its “minimized view”. This way, you can keep on working on a document or spreadsheet and still have your todo list within view. You don’t even need to go into detailed view to edit a task. But if you need more screen real estate, the full view is just a ⌘1 away.Other features include the ability to work offline, seeing flagged emails, and sharing lists with friends and family. Typing a “#” in a list automatically pops up the tag list. Sadly, Microsoft says that Planner integration isn’t there yet.AdChoices广告With the addition of macOS, Microsoft To-Do is now available on almost all major platforms. That includes Android, iOS, Windows, and the Web for everything else. Whether it has what it takes to take on the likes of Todoist is, however, a different question entirely. When Microsoft bought popular list app Wunderlist, there were fears that it would sunset the app and service just like it did with Sunrise Calendar. Microsoft didn’t leave these users hanging and did confirm the inevitable but not until it has made its own replacement is ready. That day may now be fast approaching as it announces that Microsoft To-Do is finally available in the last missing platform: macOS.
Aging Population’s Demand For Care Soars In Calif. While Oregon Puts In Place New Long-Term Care Insurance Rules News outlets report on the growing need for long-term care and offer insights into the home care workforce. California Healthline: AARP Study: California Faces Soaring Demand For Long-Term CareCalifornia faces soaring demand for long-term care services, with a senior population expected to surge 90% by 2032, according to a new study by AARP. The number of seniors age 85 and over — those most likely to need long-term care — will grow by 78%, significantly faster than the U.S. average, the report said. Most people in that demographic category live below 250% of the federal poverty line and will probably qualify for need-based long-term care and other forms of public support, AARP researchers predicted (Hart, 10/15).Kaiser Health News: Putting The ‘Care’ Into Long-Term Care InsuranceOregon, for example, has new rules on how to appeal a denial on a long-term care insurance claim. Previously, the only way to appeal a decision was in court, an arduous process for a person who may be elderly, sick and in a nursing home (Foden-Vencil, 10/17).Meanwhile, NPR offers a pair of stories exploring issues related to the home care workforce – NPR: Home Health Aides Often As Old As Their ClientsAs America ages, its 2.5 million home health workers are graying right along with the clients they care for. And by all accounts, these older workers are especially well suited to the job (Ludden, 10/17).NPR: Home Health Aides In Demand, Yet Paid LittleThe home care workforce — some 2.5 million strong — is one of the nation’s fastest growing yet also worst paid. Turnover is high, and with a potential labor shortage looming as the baby boomers age, there are efforts to attract more people to the job. One such effort plays out in a large, sunny room in a Bronx high-rise, where Cooperative Home Care Associates holds an extensive, monthlong training program. On a recent day, two dozen women paired off at rows of hospital beds. As instructors coached them, they took turns lifting each other in a mechanical sling, or gently stretching each other’s limbs, as is commonly done for stroke patients (Ludden, 10/16). This is part of the KHN Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.
New Data Help Explain Hospital Pricing, But Experts Caution That Medicare And Insurers Get Much Lower Rates This is part of the KHN Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription. Although the government releases a list of what hospitals across the country charge for common procedures in an effort to make health costs more transparent, few patients or their insurers pay that.The Wall Street Journal: Data Shine Light On Hospital BillsThe release of government data showing wide variation in hospital pricing removes a layer of secrecy but probably won’t make medical charges more uniform, experts said Wednesday. … Hospitals are required to set an official value of treatment for a given procedure, but private insurance carriers, Medicare and Medicaid—covering low-income people—all negotiate their own reimbursement rates with providers. Some uninsured people could be billed for the list price, although the amount they end up paying is also often subject to negotiation (Radnofsky and Barry, 5/8).Los Angeles Times: Hospital Prices Diverge Wildly, U.S. Data ShowNew Medicare data reveal wildly varying charges among the nation’s hospitals for 100 of the most common in-patient treatments and procedures, calling into question medical billing practices just as U.S. officials try to rein in rising costs. The escalating price of medical care may complicate the rollout of the new federal healthcare law, which is designed to make health insurance affordable for millions of uninsured Americans next year. And federal officials said they hope the data will encourage more price competition and make consumers better healthcare shoppers (Terhune and Poston, 5/8).Politico: Big Price Swings Among Hospitals Driving CostsAlthough the data are only available in a dense Excel spreadsheet, administration officials say they’re hopeful to crunch the numbers in a way that’s more accessible to consumers. It also comes on the heels of a Time magazine story by Steve Brill, which highlighted hospitals’ use of “chargemaster” lists of procedure prices. “This release helps to highlight the opaque pricing/payment system used in health care, and along with the recent Time magazine story, should increase the public awareness of this fact,” said Don Taylor, a public policy professor at Duke University. In response to the HHS release, Brill hailed the “fire hose of data — which prints out at 17,511 pages” as a “tipsheet for reporters in every American city and town, who can now ask hospitals to explain their pricing” (Cheney, 5/9).The Associated Press: High Hospital Bills Go Public, But Will It HelpFor the first time, the government is publicly revealing how much hospitals charge, and the differences are astounding: Some bill tens of thousands of dollars more than others for the same treatment, even within the same city. Why does a joint replacement cost 40 times as much at one hospital as at another across the country? It’s a mystery, federal health officials say (Cass and Neergaard, 5/9).Marketplace: Let’s Go Shopping For Surgery: New Government Data Shines Light On Health Care Cost Variations (Audio)Let’s say you needed a pacemaker and you went to Uniontown hospital in Uniontown, Pennsylvania, the charge might be $20,000. If you went to Phoenixville Hospital near Philadelphia, the charge might have been $211,000. Hospitals list radically different charges “because they can,” says Gerard Anderson, director of the Johns Hopkins Center for Hospital Finance and Management. “Nobody’s been looking at their charges over the last 30 years.” In the past, hospitals have kept their charges hidden, according to Peter Ubel , professor of Business Administration and Medicine, at Duke University. “If I’m negotiating prices with insurers, I don’t want people to know about it” (Ben-Achour, 5/8). The Fiscal Times: Why Your Hospital Bill Is Total NegotiableYesterday, for the first time, the government revealed how much hospitals charge for 100 of the most common medical procedures. The data revealed a seemingly random pricing scheme with the cost of the same procedure varying by tens of thousands of dollars from hospital to hospital. But it also painted a misleading picture of how the health care system works. Hospitals charge prices they know Medicare will not pay. They use these high prices as a starting point for negotiation and in the end, Medicare and private insurance pay just a fraction of the original charge. Consumers rarely foot the bill (Francis, 5/9).Kaiser Health News: Capsules: Audio: Getting To The Bottom Of Hospital PricingThe Centers for Medicare & Medicaid Services released data Wednesday on variations in hospital pricing and how much Medicare has actually paid to individual hospitals for various procedures. Jordan Rau joined NPR’s “Talk of the Nation” Wednesday afternoon to discuss what the data tell us about the the cost of health care and whether higher prices are correlated with better quality (5/9).Meanwhile, AP profiles two friends facing big medical bills and their efforts to help each other.The Associated Press: 2 Florida Teens Who Are Best Friends Help Each Other Pay For Expenses During Cancer TreatmentAshley was diagnosed with T-cell lymphoma in September. She needed a bone marrow transplant and would be in isolation for months. Tony knew how that would affect Ashley’s family financially. … Starting with a garage sale and car wash, he gathered donations. Then he opened an account with www.giveforward.com, a site dedicated to raising money for people with medical bills. Within months, Tony raised about $25,000 for Ashley. Ashley’s mom, Pat Myers, who had quit her job as a website programmer so she could care for her daughter, was overwhelmed. Myers recalled thinking: “I hope we never have to repay the favor.” But two weeks after Ashley’s diagnosis, Tony discovered his cancer returned. He would need costly treatment in Bethesda, Md., at the National Institutes of Health. Ashley, from her hospital bed, told her mother that she wanted to start an online fundraiser for her friend (5/9).
This week, the Pacific Legal Foundation will make oral arguments in the U.S. Court of Appeals for the District of Columbia. Its challenge claims the health law imposes new taxes unconstitutionally. Meanwhile, a Connecticut couple has filed a lawsuit against the state’s online insurance marketplace over “moral principles” because they can’t buy a health plan on the exchange that excludes abortion coverage.The Associated Press: Group Challenges Health Law As Unconstitutional The Sacramento-based Pacific Legal Foundation this week will take another step in its challenge to President Barack Obama’s health care law, claiming it imposes new taxes unconstitutionally. The foundation, which advocates for limited government, is scheduled to make oral arguments Thursday in the U.S. Court of Appeals for the District of Columbia. A district court ruled last year against the foundation, which filed the case on behalf of Iraq war veteran and Washington state small business owner Matt Sissel (Lin, 5/5). The CT Mirror: Couple Sues Over Abortion Coverage In Access Health CT PlansThanks to subsidies under the Affordable Care Act, Barth and Abbie Bracy of Dayville can buy a comprehensive health insurance policy through Access Health CT for only $2.63 a month. But they are suing the exchange, and federal officials, over what they say are moral principles. Barth Bracy is executive director of Rhode Island State Right to Life and a deacon at his Catholic church. He and his wife strongly oppose abortion. With the help of a conservative, pro-life group, the couple is suing Access Health CT, outgoing Secretary of Health and Human Services Kathleen Sebelius and other federal officials because they say Connecticut’s health exchange does not offer any policies that exclude abortion coverage (Radelat, 5/5). More Court Hearings For Health Law Legal Challenges This is part of the KHN Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.
Whether working as a drag queen or a government employee, LeQuan Edwards always managed to find a bathroom to use. Edwards, 52, is transgender. From where she’s been sitting these past few months — a hospital bed in Des Moines — her struggle to be treated like anyone else has never been so great. Her current problem is a national one and arguably more critical than the one a Florida congressman recently dubbed The Great Bathroom Debate. Iowa’s Civil Rights Act expressly prohibits discrimination based on gender identity. Still, Edwards’ caregivers have been unable to find a place for her to live. (Rood, 5/18) The Des Moines Register: Nursing Facility Doors Slam Shut For Transgender Iowan State and federal officials have reached agreement on how Georgia can improve and expand services for people with developmental disabilities and mental illness, building on the terms of a landmark 2010 pact. (Miller, 5/18) The Senate is expected to make a handful of changes on Wednesday to a House-passed medical marijuana bill, including who is responsible for crafting the rules and regulations. (Siegel, 5/18) Late last month Tennessee Governor Bill Haslam signed legislation allowing counselors and therapists to use their “sincerely held personal beliefs” as a basis for rejecting patients, the first law of its kind. (Konrad, 5/19) A Florida man killed his wife earlier this week because he said he could no longer pay for her medication, according to authorities. William Hager, 86, told the St. Lucie County sheriff’s officials that his wife of more than 50 years was in poor health and pain. He said he could no longer afford to pay for Carolyn Hager’s medication, so he shot her in the head on Monday with a .32-caliber revolver as she slept. He put the gun down, drank coffee and then contacted family members and told them that he killed the 78-year-old. (Greenlee, 5/18) Nearly 90 percent of Colorado residents infected with hepatitis C, now the deadliest infectious disease in the United States, are going untreated, a new report estimates. (Olinger, 5/18) This is part of the KHN Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription. USA Today/St. Lucie (Fla.) News-Tribune: Man Says He Killed Sick Wife Because He Couldn’t Afford Her Medication Heather Meadows will never know what it’s like to see her infant daughter and 6-year-old son grow up. She won’t reach mid-life… Instead, the 29-year-old mother has become the latest face of an issue that merits serious and determined action from authorities: the growing death toll at South Florida’s shadowy cosmetic surgery clinics. (Santiago, 5/19) The Richmond Times-Dispatch: HDL Fights Department Of Justice Subpoena CBS News: A New Headache For Mental Health Patients The Associated Press: Amid Budget Deficit, Illinois Considers Taxing Sugary Drinks The Associated Press: House To Decide On Ban On Online Eye Exams For Prescriptions The South Carolina House will decide whether companies can offer prescriptions for glasses and contacts after online eye exams. The Senate voted 39-3 Wednesday to override Gov. Nikki Haley’s veto of a bill banning the practice. An override in the House would bar prescriptions based solely on a computerized eye test. That chamber passed the bill 100-1 last month. (Adcox, 5/16) The Associated Press: Democrats, Republicans Clash Over Cigarette Tax In Oklahoma The Denver Post: Ninety Percent Of Colorado Residents With Hepatitis C Going Untreated Health Diagnostic Laboratory is attempting to avoid getting dragged back into a federal lawsuit that it settled its way out of last year. (Demeria, 5/18) State Highlights: Georgia Strikes Mental Health Services Deal With Feds; States Consider Soda, Cigarette Taxes Outlets report on health news in Georgia, Illinois, Oklahoma, Tennessee, Virginia, Colorado, South Carolina, Iowa, Florida and Ohio. The Miami Herald: In Search Of Bigger Butts, Women Find South Florida Death Traps The Oklahoma House rejected a proposed $1.50-per-pack tax on cigarettes to help stave off cuts to the state’s health care system, with Democrats uniting against the plan until it includes an expansion of Medicaid for the working poor. (Murphy, 5/18) The Columbus Dispatch: Ohio Senate Looks To Tweak Medical Marijuana Proposal Georgia Health News: Georgia, Feds Reach Deal On Fixing 2010 Agreement Lawmakers scrambling to find money to fix Illinois’ multibillion dollar deficit are looking to sugary drinks as one potential source of revenue. Taxing distributors of sodas, energy drinks and other sugary beverages was among the revenue-generating ideas a group of lawmakers proposed to Gov. Bruce Rauner and other legislative leaders last week to try to finally end a nearly yearlong impasse that’s left the state without a budget. (5/18)
The lowdown on who pays Trump’s tariffs: Is it, as he says, China, or U.S. customers and companies? ‘We never had 10 cents coming into our Treasury; now we have billions coming in’ from China, the president has said. But he’s wrong More U.S. President Donald Trump says China pays the tariffs he has imposed on US$250 billion of Chinese exports to the United States.But that is not how tariffs work. China’s government and companies in China do not pay tariffs directly. Tariffs are a tax on imports. They are paid by U.S.-registered firms to U.S. customs for the goods they import into the United States.Importers often pass the costs of tariffs on to customers — manufacturers and consumers in the United States — by raising their prices. Vietnam is cracking down on Chinese goods relabelled illegally by exporters trying to beat U.S. tariffs Australia dodges Trump tariffs on metals, thanks to U.S. politicians U.S. ‘not ready’ to make a trade deal with China, Trump says U.S. business executives and economists say U.S. consumers foot much of the bill through rising prices.White House economic adviser Larry Kudlow has acknowledged that “both sides will suffer on this,” contradicting the president.The tariff bill is set to rise further. Trump this month directed U.S. Trade Representative Robert Lighthizer to launch the process of imposing tariffs on the remaining US$300 billion of goods from China. That includes products ranging from cellphones to baby pacifiers.That would mean almost all imports from China would be subject to a 25 per cent import tax.Almost all imports from China could be subject to a 25 per cent import tax 1 Comments Reddit Share this storyThe lowdown on who pays Trump’s tariffs: Is it, as he says, China, or U.S. customers and companies? Tumblr Pinterest Google+ LinkedIn How tariffs really workU.S. Customs and Border Protection (CBP) collects the tax on imports. The agency typically requires importers to pay duties within 10 days of their shipments clearing customs.Through May 1, Washington has assessed US$23.7 billion in tariffs since early 2018, according to data from the CBP.Total tariff revenue — including levies that pre-dated Trump – shot up 89 per cent in the first half of the current fiscal year that started Oct. 1, to a total of US$34.7 billion, according to U.S. Treasury data.Every item imported into the United States legally has a customs code. Importers are expected to check the tariffs and other taxes and duties due on the goods they bring in, calculate what they owe and pay it.U.S. Customs reviews payments and sends importers a fresh bill if it detects underpayment.Importers also have to post payment guarantees, or import bonds, with customs. The costs of these bonds have risen with tariffs, an additional burden on U.S.-based firms importing goods from China.Do Chinese suppliers bear the costs of U.S. tariffs?Chinese suppliers do shoulder some of the cost of U.S. tariffs in indirect ways. Exporters sometimes, for instance, are forced to offer U.S. importers a discount to help defray the costs of higher U.S. duties. Chinese companies might also lose business if U.S. importers find another tariff-free source of the same goods outside China.And outside of tariffs, the Trump administration’s decision to add China’s Huawei, the world’s largest telecom equipment maker, to a trade blacklist, has hit that company hard.But U.S.-based importers are managing the higher tax burden in a number of ways that hurt U.S. companies and customers more than China.Such strategies include accepting lower profit margins; cutting costs — including wages and jobs for U.S. workers; deferring any potential wage hikes, as well as passing on tariff costs through higher prices for U.S. consumers or companies.Most importers use a mix of such tactics to spread the higher costs among suppliers and consumers or buyers.John Deere & Co. has had to cut costs and increase prices to make up for higher material costs. What you need to know about passing the family cottage to the next generation Reuters Comment Reuters file photo Postmedia file photo Recommended For YouMarkets mostly recover from deep losses on Trump tweet about ChinaYields little changed by jump in U.S. consumer pricesPosthaste: The unsinkable Canadian dollar, Brexit risk rising and CannTrust’s stock meltdownTrans Mountain construction work can go ahead as National Energy Board re-validates permitsDavid Rosenberg: Deflation is still the No. 1 threat to global economic stability — and central banks know it A growing number of U.S. companies has warned about the negative impact of the tariffs on U.S. consumers.Nike Inc. and 172 other footwear companies have urged Trump to remove footwear from a list of imports facing a proposed extra 25 per cent tariff, warning the move could cost consumers an additional US$7 billion a year.Walmart Inc., the world’s largest retailer, and department store chain Macy’s Inc. have warned that prices for shoppers will rise due to higher tariffs on goods from China.What the “Tariff Man” saysTrump, who has called himself the Tariff Man, has often repeated that China pays for U.S. tariffs on its goods.“We have billions of dollars coming into our Treasury — billions — from China. We never had 10 cents coming into our Treasury; now we have billions coming in,” he said on Jan. 24.On May 5, he tweeted: “For 10 months, China has been paying Tariffs to the USA.”As well as imposing tariffs on Chinese goods, Trump has also imposed a tax on global steel and aluminum imports and shipments of washing machines and solar panels.President Trump has also imposed a tax on global steel and aluminum imports and shipments of washing machines and solar panels. Signs with the U.S. flag and Chinese flag are seen at the Qingdao free trade port area in Qingdao in China’s eastern Shandong province.AFP / Getty June 19, 20194:28 PM EDT Filed under News Economy Join the conversation → Facebook ← Previous Next → Email Twitter advertisement Sponsored By: Featured Stories Higher prices for tractors, washing machinesHigher duties on imports of metals and Chinese products, for example, increased Caterpillar’s production costs by more than US$100 million last year. In response, the heavy-duty equipment maker increased prices for its products.Tractor manufacturer Deere & Co estimates a US$100 million increase in its raw materials costs this year because of Trump’s tariffs on Chinese imports. Deere has cut costs and increased prices to protect its profits.A Congressional Research Service report in February found that the tariffs boosted washing machine prices by as much as 12 per cent from January 2018, before tariffs took effect.Steel and aluminum tariffs increased the price of steel products by nearly nine per cent last year, pushing up costs for steel users by US$5.6 billion, according to a study by the Peterson Institute for International Economics.U.S. companies and consumers paid US$3 billion a month in additional taxes because of tariffs on Chinese goods and on aluminum and steel from around the globe, according to a study by the Federal Reserve Bank of New York, Princeton University and Columbia University. Companies shouldered an additional US$1.4 billion in costs related to lost efficiency in 2018, the study found.What do companies in China pay?China has retaliated against U.S. tariffs by imposing its own tariffs on imports from the United States.Most importers in China are Chinese. So in the same way the U.S. government collects import taxes on Chinese goods from U.S. importers, the Chinese government takes in taxes on U.S. goods from Chinese importers.As with tariffs in the United States, Chinese firms can seek to pass on the costs to U.S. exporters. Some U.S. interests have lost business, such as U.S. soy farmers.Chinese buyers have cut billions of dollars of soybean purchases from the United States because China’s tariffs have made U.S. supplies more expensive than beans from competitors such as Brazil.
Email More Join the conversation → Reddit ← Previous Next → Bank of Canada Governor Stephen Poloz’s team will not raise rates this year, predicts BlackRock.Justin Tang/Bloomberg Recommended For YouCyclica and University of Toronto Stagljar Lab Announce Partnership to Create the Next-Generation EGFR Inhibitors in Non-Small Cell Lung CancerAndersen Global Enters Senegal, Expands Presence in AfricaU.S. manufacturing output climbs for second month in JuneNew Guidelines for Patients Suffering From Mucositis or Oral Ulcerations From Head and Neck Cancer Treatment Can Now Be Effectively Treated With MedX’s Light Therapy DevicesHomeowners Can Beat the Heat With Central Air Conditioning advertisement Katherine Greifeld The world’s largest money manager expects the Bank of Canada to hit the brakes on policy tightening in 2019.With officials set to convene in Ottawa, BlackRock Inc. says the central bank will probably hold rates steady until at least next year as Canadian growth cools and lower oil prices work their way through the economy, weighing on the inflation outlook. Short-end traders largely agree: Overnight index swaps are barely pricing in any tightening over the next 12 months.What’s the rush to get to neutral if inflation’s not an issueBlackRock’s Aubrey Basdeo 0 Comments Share this storyWorld’s biggest money manager expects Bank of Canada to hit the brakes in 2019 Tumblr Pinterest Google+ LinkedIn Investors have slashed expectations for hikes following a dovish December policy meeting and amid a broad reassessment of the prospect of central-bank tightening as global growth shows signs of slowing. Given increased market volatility and more restrictive financial conditions, the BOC will likely pause to see the effects of its five rate hikes since mid-2017, according to BlackRock’s Aubrey Basdeo. What does the year hold for Canadians? Watch Outlook 2019 More people are going broke in Canada as interest rates rise Biggest trade deficit in 6 months adds to evidence Canada’s economy is entering soft patch “The bank has latitude to go on an extended pause,” said Basdeo, the firm’s Toronto-based head of Canadian fixed income. “What’s the rush to get to neutral if inflation’s not an issue?”The Canadian dollar sank almost 8 per cent against the greenback in 2018, the second-worst performer among Group-of-10 currencies, although it’s rebounded along with oil to start 2019. Basdeo expects the dollar-loonie pair to stick to a 76.92-73.52 US cent range as policy makers take a wait-and-see approach, from about 75.11 US cents currently.Different ViewNot everyone agrees. Morgan Stanley recommended shorting the greenback against the Canadian dollar in a note to clients Monday, targeting a move to 78.1 US cents. While a sputtering housing market and weak business investment pose challenges to the Canadian economy, “the risk of a hawkish surprise is growing” from the Bank of Canada given such low market expectations.“Increasing prospects for a weaker USD, an underpriced BOC curve, increasingly balanced risks on oil and supportive technicals suggest USD/CAD should fall from here,” wrote foreign-exchange strategists David Adams and Sheena Shah.Citigroup Inc., while anticipating policy makers will keep rates unchanged Wednesday, sees a 40 per cent chance of a hawkish hold, and recommends clients short the U.S. dollar relative to the loonie ahead of the meeting.“Disappointment to dovish expectations may trigger a bullish CAD reaction as the BOC is interpreted as one of the most hawkish central banks within the G-10,” FX strategist Kiranpal Singh wrote Monday.Bloomberg.com Facebook Twitter January 8, 20191:37 PM EST Filed under News Economy Bloomberg News World’s biggest money manager expects Bank of Canada to hit the brakes in 2019 BlackRock says central bank will hold rates steady until at least next year — and traders largely agree What you need to know about passing the family cottage to the next generation Sponsored By: Featured Stories Comment
A lightweight, small city EV worth called SIN?Danish bike manufacturer Biomega introduced a concept electric car called SIN. It’s 4-door, 4-seat CUV-type vehicle in Scandinavian design style, that comes with 4-motors (60 kW total) and 20 kWh battery for up to 160 km (100 miles) of range.The secret of SIN is in the curb weight of just 950 kg (including a 200 kg battery) that enables it to use a small battery. Moreover, 6 kWh out of 20 kWh is removable (three 2 kWh modules) – “allowing the battery to be replaced on the move, and extra distance to be covered between charges”.If Biomega decides to launch it into production, then SIN is expected in 2021-2023.See Also Denmark Plug-In Vehicles Sales Tank As Subsidies Vanish 5 photos Author Liberty Access TechnologiesPosted on November 7, 2018Categories Electric Vehicle News “SIN creates a new open-wheel vehicle typology that allows for a flat floor and easy maneuvering in tight urban spaces, while the invention of a fascia window maximizes road view.SIN is designed to be built using state-of-the-art lightweight composites, including a world-first use of modular carbon fiber for high volume automotive production. Through uncluttered interior, the car rejects superfluous styling in favor of low cost, comfort and sustainability.”See video here.Base Specs (preliminary):Price: €20.000Max. power in kW: 60 kW (82 hp)Max. torque in Nm: 160 NmAcceleration 0 – 100 km/h (62 mph): 13 sTop Speed in km/h: 130 km/h (209 mph)Range in km: 160 km (100 miles)Battery capacity in kWh: 20 kWh (14 + 6 kWh removable)Battery weight: 200 kgBattery weight kg/kWh: 10kg / kWhPower consumption: 11 kWh / 100 kmKerb weight: 950kgStructure CFRP body shell structure with aluminum crossbeamsMotors 4 in-hub motors on external wheelsBattery Pack Main battery pack on floor + modular swapping battery system Denmark Embraces Electric, Moves To Ban Diesel & Gas Source: Electric Vehicle News Following Tesla Sales Crash, Denmark Reconsiders EV Incentives
Porsche Taycan, the German premium automaker’s first all-electric vehicle, is being put to the test by rally legend Walter Röhrl as part of its development program ahead of the launch later this year. more…The post Porsche Taycan is put to the test by rally legend Walter Röhrl appeared first on Electrek. Source: Charge Forward
All-electric Polestar 2 will start around $45,000 and offer about 275 miles of range based on the EPA cycle.We often joke about Tesla killers or Tesla fighters. However, there’s not much truth to either as proven by the incredible success of the Tesla Model 3 as compared to any potential rivals. Not to mention that the Model S and Model X don’t really even have direct competitors that have proven much of anything in terms of sales. Finally, another small, sporty all-electric car will come to market as a true Model 3 rival. Volvo is releasing the car from its former performance sub-brand, Polestar.More Polestar 2 Coverage: According to the automaker, the car will start at 39,900 Euros, about $45,400 USD. However, a launch edition will set you back some 59,900 euros ($68,200). The special launch edition will be available for the first year of Polestar 2 production. The upcoming entrant will be manufactured in China and available in 2020. Meanwhile, Polestar already has plans to take it on a worldwide marketing tour beginning next month.The Polestar 2 comes as the first mainstream offering from the Volvo sub-brand. Polestar 1 precedes it, however, it’s limited to 500 pricey copies (starting at $155,000). In addition, Polestar 1 is a plug-in hybrid electric vehicle, rather than a battery-electric car. Chief Executive Officer of Polestar Thomas Ingenlath shares:Polestar 2 is our first fully electric car and first volume model. Everything about it has been designed and engineered with passion and dedication. As an electric performance brand, and through the forthcoming launch of a portfolio of fully electric cars, Polestar is determined to address the world’s air quality challenges. Polestar delivers electric performance cars that are great to own and drive.The Polestar 2 boasts over 400 horsepower, and a zero-to-62-mph time of 5 seconds. It features two electric motors (standard all-wheel drive) and a 78 kWh battery pack, churning out 660 Nm (487 pound-feet of torque). Polestar notes that it’s one of the first cars to offer a standard infotainment system that’s centered around Android Auto, which comes as an option in many cars and is not available in any of Tesla’s vehicles. 2020 Polestar 2 Debuts Today: See The Livestream: UPDATE 16 photos Author Liberty Access TechnologiesPosted on February 27, 2019Categories Electric Vehicle News How Polestar 2 Compares With Tesla Model 3 Check out the entire press release below:Polestar reveals new Polestar 2Polestar has taken the next step in its development as the electric performance brand with the reveal of the new Polestar 2. Polestar 2 is the new all-electric fastback that brings electric performance cars to a broader and increasingly progressive audience. It offers avant-garde design and a unique customer experience in the premium compact electric segment. Polestar 2 is the first electric car to compete in the marketplace around the Tesla Model 3, with the range starting at a guide price of 39,900 euros. For the first 12 months of production, guide price of the launch edition is 59,900 euros1.“Polestar 2 is our first fully electric car and first volume model. Everything about it has been designed and engineered with passion and dedication. As an electric performance brand, and through the forthcoming launch of a portfolio of fully electric cars, Polestar is determined to address the world’s air quality challenges. Polestar delivers electric performance cars that are great to own and drive,” says Thomas Ingenlath, Chief Executive Officer of Polestar.Polestar 2 is a premium five-door fastback with two electric motors and a 78 kWh battery capacity2 that will enable a targeted range of 500 km3, based on Volvo Car Group’s adaptable Compact Modular Architecture platform (CMA). The 27-module battery pack is integrated into the floor and contributes to the rigidity of the chassis as well as improves the car’s noise, vibration and harshness (NVH) levels – road noise has been reduced by 3.7 dB compared to a traditional chassis.Polestar will answer the important question of charging Polestar 2 with a smart, convenient and extensive approach. With a connected digital solution available both in-car and on mobile devices, Polestar is setting up strategic collaborations to give Polestar 2 owners easy and hassle-free access to the world’s largest public charging networks.For Polestar, performance underlies the entire driving experience. The all-wheel drive electric powertrain in Polestar 2 produces 300 kW (408 hp) and 660 Nm (487 lb-ft). This translates to a 0-100 km/h acceleration time of less than 5 seconds.The standard dynamic chassis can be enhanced by the Performance Pack that improves driving dynamics with Öhlins dampers, Brembo brakes and unique 20-inch forged wheels. Polestar’s signature gold seat belts, brake callipers and valve caps complete the performance visuals.Highlighting the technology spearhead role that Polestar plays within the Volvo Car Group, Polestar 2 is one of the first cars in the world to embed an infotainment system powered by Android. The Android backbone provides a solid and adaptable digital environment for apps and vehicle functions to coexist, and brings embedded Google services to a car for the first time – including the Google Assistant, Google Maps with support for electric vehicles and the Google Play Store5. Natural voice control and a new 11-inch touch screen display bring the new interface to life.Phone-as-Key technology enables car sharing and a more integrated ownership experience, as well as Polestar’s connected services such as pick-up and delivery. It also allows Polestar 2 to sense the driver upon approach. Smart features like enlarged graphics in the instrument cluster allow the driver to easily see the charging status and range before entering the car. Polestar 2 can also predetermine the driver’s next move to create a seamless experience with a prepared cabin and quick start sequence.Maximilian Missoni, head of Design at Polestar, comments: “We decided to bring something different to the segment. Our avant-garde design has evolved from Polestar 1 into an edgier, bolder statement. We have also designed a standard vegan interior with progressive textiles that will appeal to the forward-thinking audience who will subscribe to Polestar 2.”Design-led features include Pixel LED headlights4 and proximity lighting which enable a unique welcome sequence, Polestar’s now-signature frameless side mirrors and the unique illuminated Polestar logo, which is reflected onto the car’s panoramic glass roof.In common with all Polestar cars, Polestar 2 will only be available for ordering online. The guide purchase price for the launch version of Polestar 2 is 59,900 euros1 with subscription pricing to follow at a later date. Pre-orders are open at polestar.com. Production of Polestar 2 begins in early 2020 in China for global markets in both left- and right-hand drive.Polestar 2 will make its first public appearance at the 2019 Geneva International Motor Show in March, and then embark on a global roadshow in Europe, North America and China throughout 2019. Polestar 2 will also be available in a network of soon-to-be-opened Polestar Spaces that will provide physical viewing and test drive opportunities.Initial launch markets include China, the United States, Canada, Belgium, Germany, the Netherlands, Norway, Sweden and the UK. Other markets are under consideration for future expansion.Ends.Notes to editors:1. Guide pricing:EUR: 39,900-59,900 based on the German market and local taxes;USD: 63,000 for the launch edition. Less the federal incentive of 7,500 USD = 55,500 USD for the launch edition;RMB: pricing in China will be announced at a later date.2. China: 72 kWh.3. Targeted 500 km range on WLTP (Europe) and NEDC (China) test cycles. Targeted 275 miles EPA (US).4. Standard LED headlights fitted in US and Canada (legislation restrictions).5. Google, Google Maps, Google Play and other related marks and logos are trademarks of Google LLC.About PolestarPolestar is the electric performance car brand jointly owned by Volvo Car Group and Zhejiang Geely Holding. Polestar enjoys specific technological and engineering synergies with Volvo Cars and benefits from significant economies of scale as a result. This facilitates the successful design, development and production of separately-branded, electric performance cars.Polestar launched in 2017 with the Polestar 1 – a low-volume Electric Performance Hybrid GT with 600 hp, 1,000 Nm and an electric-only range of 150 km – the longest of any hybrid car in the world. In 2019, the Polestar 2 was revealed as the company’s first full electric, higher volume premium car designed to compete around the Tesla Model 3. In the future, Polestar 3 will join the portfolio as a fully electric performance SUV.Polestar also applies its technology and expertise to electrified Volvo cars. The Volvo S60 T8 Polestar Engineered features key Polestar components to create a sharper and more engaging driving experience. Polestar optimisation software upgrades are also available for Volvo models, which enhance six performance areas including engine output. Polestar Engineered media information can be found on the Volvo Cars media website.Source: Polestar Source: Electric Vehicle News Volvo Teases Polestar 2 Again Ahead Of Reveal
Let’s See The New Formula E Gen 2 Battery: Video The pair were running third and fourth during the race at Mexico City when they ran out of energy on the final lap and were forced to stop, which Buemi explained afterwards was down to a strategy software mistake.More Formula E News When asked how the team had reacted to the problem ahead of this weekend’s race in Hong Kong, Rowland told Motorsport.com that: “They were disappointed, obviously, and they’ve put precautions in place to make sure it doesn’t happen again.“From my side it was all done and dusted within an hour of the race and you just have to look forward to the next one. I’m trying not to think about that too much.“We weren’t 100% sure [about the energy level] and there was other calculations going on and unfortunately the back-up failed as well.“It’s just one of those things – I don’t think it will ever happen again so I’m not too worried.”Buemi explained that the miscalculation occurred just after the race’s red flag period – caused by the accident between Nelson Piquet Jr and Jean-Eric Vergne – was called.“The data from the lap after the red flag was wrong, which offset the whole timing until the end,” he told Motorsport.com.“But then because of that we had the wrong values and we ended up driving for a lap less.“We were quite close to [the race being] one more or one less lap – we crossed the line within nine seconds – so the mistake was around 20-seconds.”Team radio released after the Mexican event revealed the shock both Nissan drivers experienced when they released they would not make the finish of the race.Buemi said that his words were a reflection of his “emotions directly” in the cockpit and compared the situation to the 2016 Le Mans 24 Hours, which he was on-course to win when his Toyota teammate Kazuki Nakajima stopped on the penultimate lap.“Apparently they saw one lap before that there was a mistake,” he said.“I didn’t get it on the radio that they knew before we crossed the line that it was going to happen, so it happened to me as a shock.“I was ashamed because the work that comes into place – simulator work, the qualifying, the superpole and then when you do 99% of the job to finally score big points, it’s quite hard to accept.“But we are a team – that was emotions directly – when I got to the garage I said ‘guys, we move on and we understand what happened and we come back and we’re going to do better’.“It’s just hard to accept when it happens on the last lap – a bit like Le Mans in 2016 when I stopped on the last lap. [It was] quite similar – it’s hard to swallow.” Angry Vergne Says Recent Formula E Shunts “Not Motorsport” Source: Electric Vehicle News Buemi “Speechless” At Nissan’s Formula E Energy Miscalculation Author Liberty Access TechnologiesPosted on March 9, 2019Categories Electric Vehicle News Nissan e.dams has added “precautions” to its energy management software following the miscalculation that ruined its ABB FIA Formula E race in Mexico, according to Oliver Rowland and Sebastien Buemi
Source: Charge Forward Best Buy offers two TP-Link HS105 Smart Plug Minis for $27.98 shipped. As a comparison, Amazon currently offers this bundle at $45. Today’s deal is $2 less than our previous mention. This two-pack is an easy buy at just $15 per plug as an affordable way to expand your smart home. Features include support for Alexa and Google Assistant, a minimalistic design that only covers one outlet and more. Put the free smartphone app to work and create schedules, which help cut down on unnecessary energy usage. Rated 4.7/5 stars. more…The post Green Deals: 2-pack TP-Link Smart Plug Minis $28, more appeared first on Electrek.
Source: Charge Forward In a move motivated more by politics than attempts to find legislative solutions, Senate Republicans put the Green New Deal up for a vote on Tuesday, and the results were unsurprising. All Republicans (and a few Democrats) voted “no,” and the rest of the Democrats simply marked their vote as “present.” more…The post Senate vote on Green New Deal goes mostly as expected: 57 no, 43 ‘present’ appeared first on Electrek.
Sunderland Fri 2 May 2008 20.58 EDT Roy Keane will ask Sunderland’s board to revise the club’s wage structure this summer and urge his directors to start enticing potential new recruits with salaries comparable to those on offer at Newcastle United and Middlesbrough.”I know for a fact that we pay nowhere what teams near here pay, nowhere near,” said Keane yesterday. “Over the past few years players have gone to other clubs in this area rather than us because of their wage structures.”Look at the players who have been at Newcastle and Middlesbrough in the past few years. I’m pretty sure Michael Owen is not getting just £20,000 a week at Newcastle and I don’t think Gaizka Mendieta and Afonso Alves are on that at Middlesbrough either. I’m also sure Middlesbrough paid Juninho and Alen Boksic decent money too. If you want top players you have to pay them top money and we want to try and be in that bracket.”Keane, whose side visit Bolton Wanderers today, also hopes to extend Dwight Yorke’s time at the Stadium of Light, possibly by offering the veteran a player-coach role when they sit down to discuss his future next week. “Dwight’s not leaving just yet,” insisted the manager. “He’s been one of my best signings and has done everything I’ve asked of him. He’s been a great help on the field and, along with Deano [Whitehead, Sunderland’s captain] has led the dressing room.”Arsène Wenger has given Mathieu Flamini 48 hours to decide whether he wishes to stay at Arsenal but has warned the French midfielder the club will not break their wage structure to accommodate him. Flamini, 24, is a free agent at the end of the season but, despite telling Wenger he wishes to remain in north London, he has continually refused to sign their £55,000-a-week new contract offer and is now attracting interest from Milan. “It will be sorted out over the weekend, and will he stay or not that is down to him but the deadline is Monday at the latest,” Wenger said. “But we cannot afford not to keep our wage structure. We have a £360m debt and we have to respect the structure or we will go bust, it’s as simple as that.” Share via Email Share on WhatsApp Share on Facebook After a successful first season in the Premier League, Roy Keane is targeting further improvements. Photograph: Michael Regan/Action Share on LinkedIn Shares00 Share on Twitter Share on Messenger Share on Pinterest Louise Taylor Share on Twitter Topics Keane warns Sunderland board over wage levels Sunderland First published on Fri 2 May 2008 20.58 EDT Share on Facebook Share via Email Reuse this content
TweetShare108ShareEmail108 SharesIn a recent conversation, my good friend Noah brought up the tendency of industrialised capitalist cultures to isolate age groups, which eventually leads to each age group othering (or, perceiving as ‘other’) anyone born before or after them. When younger people inevitably become the older outsiders, it is common to begin neglecting the ritual of celebrating their births. Only some hold on to the tradition after their peers stop, and even fewer folks actually publicly profess their age in these instances. Milestone birthday parties seem to only be granted to those who have the social agency to afford to reveal their age.In the white, middle-class, capitalist culture in which I was raised, there was no greater ritual than that of the birthday party. With the necessary bare minimum of cake, candles, wrapped presents, and a swarm of kids around the same age as the celebrant, there were endless possibilities as to what could be added to the ceremony. There were competitive games like pin the tail on the donkey or musical chairs, with any number of themes and venues. It was an annual event which also reinforced the celebration of the individual; the addictive edge of consumerism and the segregation of younger people based on the year they were born.For someone like me, who prefers to explore the world from a pro-ageing perspective, this last month has been unusually sensational. The White House declined to censure Homeland Security Secretary Kelly Sadler when she said that whatever Senator John McCain’s opinion, it did not matter because he was ‘dying.’ Then, in New York City, billboard advertisements from a delivery service declared 30-year-olds “as good as dead.” Postmates reminded those ‘adulting’ New Yorkers with a credit card and a smartphone that they no longer had to share cake with the other kids: “When you want a whole cake to yourself because you’re turning 30, which is basically 50, which is basically dead.”Opposition from anti-ageism activists effectively challenged the billion dollar company online, and the billboards were removed. Besides being born in 1988, this ad hit a nerve for me because of the large amount of intense manual and emotional labor I have done working for this company throughout my twenties. I would go so far as to say I have, on many occasions, put my life on the line while working for this company, and I know this is also true for many others. Simply put, their advertisements, in my experience, are consistent with their business model: making money is more valuable than human life. The conflation of these messages –that the opinions of those old, dying or over thirty don’t matter– is a reproduction of the baby boomer’s motto from their youth: “don’t trust anyone over thirty”. Even though apparently Jack Weinberg never meant for this statement he said to be quoted in a 1964 article, it is without a doubt a mainstream catchphrase of that generation.It is also my experience, though, that age-pride is a much more attractive and powerful force than age-shame, even though it is not as popular as of yet. That is luckily changing, though. Pop star Pink tweeted a pro-ageing proclamation last month in response to a troll who made a “Pink looks so old” joke. After calling the troll out, she tweeted: “I am of the mindset that it’s a blessing to grow old. That if your face has lines around your eyes and mouth it means you’ve laughed a lot. I pray I look older in 10 years, cause that will mean I’m alive.” So far, the tweet has gotten 15K retweets and 99K likes. It is a powerful message, and one people obviously need to hear right now. Boiled down, it is this: aging is good. It may not seem like such a radical concept, until one considers the fact that the global anti-aging industry is worth hundreds of billions of dollars.Ageism is difficult to see precisely because it is so pervasive. Kelly Sadler and the administration, those advertisements, and Pink’s troll, are all backed up by many subtler and often hidden ageist beliefs and attitudes. If you don’t believe me, greeting cards are proof enough: systemic youth supremacist culture is rife in birthday messages arranged on racks in stores everywhere. The mystifying truth is, “aging is good” is exactly what those birthday parties I experienced as a child attempted to promote. Perhaps these rituals were so over the top because ageism had such a firm grip on the organizers, the parents: enjoy aging while you still can, before it turns on you! This ends up creating the ageist presumption that young people must accomplish as much as possible while they “still can.” Wouldn’t it be revolutionary if we all kept the attitude of enjoying aging throughout our entire lives, as some of the happiest amongst us already do?Personally, I have almost altogether abandoned mainstream rituals for more powerful and meaningful ones. On June 8th I spent my birthday at a spa just outside of Berlin where I was given the gift of free entry, two euros towards something from the cafe (I got a euro eis for my partner and one for me) and a photo, which was graced by some of my favourite people who tagged along for the sweats…Now that I am on this side of thirty I am thrilled to be aging and to continue this work as an anti-ageism activist. I believe that the eradication of ageism is helpful in also eradicating white supremacy, gender bias, ableism, body shaming, homophobia, classism, and other forms of oppression. Age is only one part of our identity, but it intersects with all the other parts of who we are. It is a universal experience, and I believe embracing this truth will help to liberate us all.Related PostsFrom Ageism to Age PrideAshton Applewhite stands before a room of dozens of people expecting to hear the same ‘ol spiel. Instead, she poses a question: “What is every person in this room going to become?” When no one offers an answer she continues. “Older. The prospect has an awful lot of us scared…Who’s Going to Create a Better Narrative of Old Age in America?Changing the culture is hard, and it involves struggle. That struggle doesn’t start in a shopping cart, whether online or at Walmart. It starts between our ears, with the uncomfortable task of confronting our own, largely unconscious, age bias.Ageism . . . Not Just for Grown-upsSitting in a local coffee shop, I recently overheard a couple of women talking about ageism and the havoc it wreaks on older people. But then, almost in the same breath, the focus of the conversation shifted to teenagers today.TweetShare108ShareEmail108 Shares
Source:http://opa.uahs.arizona.edu/newsroom/news/2018/ua-researchers-develop-novel-lung-leaf-model-study-pulmonary-diseases Jun 21 2018UA College of Medicine – Phoenix scientists cross-utilize plant biology, medicine and engineering to create novel platform.Researchers at the University of Arizona College of Medicine – Phoenix have developed a revolutionary “lung on a leaf” to study pulmonary diseases. Kenneth Knox, MD, professor and associate dean of faculty affairs and development, and Frederic Zenhausern, PhD, MBA, professor and director of the UA Center for Applied NanoBioscience and Medicine, have received a three-year, $750,000 grant from the Arizona Biomedical Research Commission to study lung infections like Valley fever and inflammatory conditions like sarcoidosis in a plant model.”The lung is a very complex organ,” Dr. Knox said. “There are not many novel ways to study the lung, but growing cells on a leaf would be a way for us to organize cell types in a biologically meaningful way to learn more about lung immunity and lung fibrosis.”Dr. Knox hopes that by using inactive Coccidioides fungus–the cause of Valley fever–to simulate inflammation, they will be better able to understand how inflammation begins, which will pave the way for new therapies.The study not only will develop an innovative model to study pulmonary disease, but the revolutionary approach, if successful, will allow researchers to bypass testing their theories on animals.”We are at a point in medicine where collaborations across disciplines are needed to take us to the next level,” Dr. Knox said. “Our goal is to move the field forward in how we model different lung diseases.”The idea for the lung on a leaf began with UA undergraduate researcher Ryan Zenhausern (Dr. Zenhausern’s son) and his mentor, Jerome Lacombe, PhD, UA assistant professor, who were developing a new cancer research model using spinach leaves. The natural spinach leaf structure was the basis for an improved in vitro (outside the body) tumor model to allow more accurate study of the causes, effects and treatment of different cancers. Dr. Knox became interested in their research from a pulmonologist’s perspective, since both a lung and a leaf possess similar branching structures.Related StoriesNew shingles vaccine reduces outbreaks of painful rash among stem cell transplant patientsSugary drinks linked to cancer finds studyNew protein target for deadly ovarian cancerDr. Zenhausern’s lab has been working on the in vitro leaf platform–research on an engineered system that mimics a living organism–since the summer of 2017.Previously, the lab developed an “organ on a chip” that mimics the human gut. With this technology, researchers can analyze the complex interactions between human cells and the microbial ecosystems of the gut, predicting their effects on health or disease.”We are developing a tool that will better mimic the human system and improve the overall concept of personalized medicine,” Dr. Zenhausern said. “We now can think about the long vision because we have those building blocks. If we can put a lung on a leaf, maybe next it will be a liver, or another organ.”The platform technology provides a 3-D tissue microenvironment that is constructed by treating a leaf with detergents to remove all traces of plant cells, DNA and proteins, leaving only its scaffold. Next, different types of cells are repopulated on the skeleton of the leaf and re-cellularized on the surface of the leaf. The stem vasculature can be populated with the appropriate cell types, which resemble blood vessels. The team hopes to use human patient cells by the third year of their grant.Co-investigators are Drs. Knox, Zenhausern and Lacombe; Ting Wang, PhD; Louise Hecker, PhD, and Mrinalini Kala, PhD.In discussing how the research could be used in other realms, Dr. Zenhausern said the lung model could be used to measure radiation exposure in cancer patients and in space, where astronauts are exposed to large amounts of radiation.”From an engineering perspective, we are cross-utilizing the different fields from plant biology, medicine and engineering,” he said. “We can create a platform technology that will be more useful in studying the entire biological system, which is very complex in medicine.”
Reviewed by James Ives, M.Psych. (Editor)Sep 7 2018Researchers are beginning recruitment in a trial to see if changing pregnant women’s hygiene habits could reduce the risks of a major cause of childhood disabilities.Cytomegalovirus, or CMV, is the most common congenital infection in the UK, affecting around 1000 babies every year. If babies are infected while in the womb it can result in serious health problems, such as cerebral palsy, developmental delay and hearing loss.Approximately one in five babies with congenital CMV will have long term health problems, which can also include seizures, sight problems, small head size and intellectual disability. Even babies born with the infection who don’t have symptoms at birth are at risk of developing hearing loss later in life.However, most pregnant women are not aware of CMV or the measures that can be taken to reduce the risk of catching it, as information about the virus is not routinely offered in the NHS. The virus is a common one and is generally harmless in adults and children.Related StoriesOlympus Europe and Cytosurge join hands to accelerate drug development, single cell researchComplement system shown to remove dead cells in retinitis pigmentosa, contradicting previous researchAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapyThe research team includes behavioral experts and clinicians from St George’s University, Kingston University, St George’s University Hospitals NHS Foundation Trust, University College London and Cambridge University. The charity CMV Action is also supporting the initiative. The team has secured funding from the National Institute of Health Research (NIHR) Research for Patient Benefit Program.The study aims to recruit 400 women who have not had the CMV virus before and who already have a child under 3 years old. It will study the impact of an educational film which has been developed by the research team on women’s hygiene practices during pregnancy and whether this can reduce the number of women who are infected with the virus. Recruitment will start during the week of 3 September.Transmission of CMV is through bodily fluids such as saliva, and the main way pregnant women catch CMV is from close contact with small children’s saliva and urine. The film gives advice about how to reduce the chances of this happening.Project lead Dr Chrissie Jones, Associate Professor in Paediatric Infectious Diseases and Immunology at the University of Southampton, said: “CMV affects more babies than Down’s Syndrome, but is still relatively unknown and advice about it does not at present form part of standard antenatal care. There is no vaccine as yet, but we believe that simple hygiene measures may make a real difference. The messages in our film are direct and involve families whose children have been affected by congenital CMV telling their stories. We hope to motivate these women to change their day-to-day activities with a consequent reduction in infection rates.”Dr Anna Calvert, Research Fellow at St George’s, University of London, said: “One of the frustrations that families whose children are affected have is that they didn’t know anything about this virus, which can have very serious implications for their children’s health. Their passion for raising awareness about it has really motivated us to undertake this study.” Source:https://www.sgul.ac.uk/news/news-archive/research-trial-aims-to-reduce-major-cause-of-birth-disabilities